Itraconazole and clarithromycin inhibit P‐glycoprotein activity in primary human sinonasal epithelial cells

Abstract

Both itraconazole and clarithromycin are capable of inhibiting sinonasal epithelial cell associated P-gp. The anti-inflammatory effects of these agents in CRS may be attributable, in part, to their heretofore unrecognized P-gp modulatory properties.