Stability of Prostaglandins

Abstract

Data on the stability of solutions of prostaglandins currently in clinical trials and information on the extemporaneous preparation of the solutions are presented. Prostaglandin E2, −5 μg/ml in saline solution, was stable at 4 C for one week and at room temperature for one day. Prostaglandin F2α, 15 μg/ml in aqueous solution, was stable at 4 C, 25 C and 47 C for one week. Prostaglandin A1, 0.05 mg/ml in saline solution, was stable for two days at 4 C and one day at 25 C. The analytical procedure for each compound is discussed.