Concepedia

Is the WHO analgesic ladder still valid? Twenty-four years of experience.

Grisell Vargas-Schaffer

PubMed · 2010 · 417 citations · 11 references

Concepts

Abstract

Pain remains one of the main reasons for medical consultation worldwide. Numerous organizations and scientific associations have made efforts to find solutions for this problem and to facilitate the treatment of pain. In 1986 the World Health Organization (WHO) presented the analgesic ladder as a

References

11

Validation of World Health Organization Guidelines for cancer pain relief: a 10-year prospective study

D. Zech, Stefan Grond, John Lynch et al. · Pain · 1995 · 1K citations

, , +10

Pharmacological Management of Chronic Neuropathic Pain – Consensus Statement and Guidelines from the Canadian Pain Society

DE Moulin, AJ Clark, Ian Gilron et al. · Pain Research and Management · 2007 · 555 citations · Full text

, , +17

Methadone Versus Morphine As a First-Line Strong Opioid for Cancer Pain: A Randomized, Double-Blind Study

Éduardo Bruera, J. Lynn Palmer, Snežana Bošnjak et al. · Journal of Clinical Oncology · 2003 · 211 citations · Full text

, , +17

Comparison of analgesic effects and patient tolerability of nabilone and dihydrocodeine for chronic neuropathic pain: randomised, crossover, double blind study

Bernhard Frank, Mick Serpell, John Hughes et al. · BMJ · 2008 · 204 citations · Full text

, , +17

The use of opioids for the treatment of chronic pain. A consensus statement from the American Academy of Pain Medicine and the American Pain Society.

PubMed · 1997 · 195 citations

, , +14