Amantadine-Oseltamivir Combination therapy for H5N1 Influenza Virus Infection in Mice

Abstract

Combination chemotherapy provided a survival advantage over single-agent treatment of mice inoculated with neurotropic H5N1 influenza virus. This strategy might be an option for the control of pandemic influenza viruses that are sensitive to amantadine. Combinations that include other drugs should be explored.