Concepedia

Microneedle-mediated intrascleral delivery of <i>in situ</i> forming thermoresponsive implants for sustained ocular drug delivery

Thakur Raghu Raj Singh, Steven J. Fallows, Hannah McMillan, Ryan F. Donnelly, David S. Jones

Journal of Pharmacy and Pharmacology · 2013 · 80 citations · 26 references

DOIFull text

Open access

Abstract

This study shows that the minimally invasive HMN device can localise in situ forming implants in the scleral tissue and provide sustained drug delivery.

References

26

Poly(ethylene oxide)poly(propylene oxide)poly(ethylene oxide) block copolymer surfactants in aqueous solutions and at interfaces: thermodynamics, structure, dynamics, and modeling

Paschalis Alexandridis, T. Alan Hatton · Colloids and Surfaces A Physicochemical and Engineering Aspects · 1995 · 1.9K citations

Diffusion of high molecular weight compounds through sclera.

Jayakrishna Ambati, Christina Canakis, Joan W. Miller et al. · PubMed · 2000 · 360 citations

Rheological evaluation of poloxamer as an in situ gel for ophthalmic use

Katarina Edsman, Johan Carlfors, Roger Petersson · European Journal of Pharmaceutical Sciences · 1998 · 332 citations

, , +10

Thermosetting gels with modulated gelation temperature for ophthalmic use: the rheological and gamma scintigraphic studies

Gang Wei, Hui Xu, Ping Ding et al. · Journal of Controlled Release · 2002 · 243 citations

, , +8

Intrascleral Drug Delivery to the Eye Using Hollow Microneedles

Jason Jiang, Jason S. Moore, Henry F. Edelhauser et al. · Pharmaceutical Research · 2008 · 204 citations · Full text

, , +7