Infection and Immunity · 1993 · 13 citations · 9 references
Veterinary MedicineImmunologyInfectious DiseasesImmunology Of Infectious DiseasesImmunopathologyInfectious Disease PathologyPulmonary InfectionsPulmonary InflammationRespiratory DiseaseRespiratory Infectious DiseasesRespiratory Tract InfectionsViral InfectionsPneumocystis InfectionPneumonia-associated InflammationPulmonary PathogenesisRespiratory Viral InfectionsRespiratory Viral PathologyRespiratory VirusesViral Respiratory Infections
scid mice naturally infected with Pneumocystis carinii and inoculated with a normally apathogenic pneumovirus had significantly higher P. carinii cyst counts and developed significantly more severe P. carinii-related disease than did sham-inoculated, P. carinii-infected scid mice. P. carinii-free, virus-infected scid mice survived for 2 months despite high pulmonary virus titers. These results show that a respiratory virus infection can exacerbate P. carinii disease in an immunocompromised-rodent model.
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