Augmented Vasoconstriction and Thromboxane Formation by 15-F_2t-Isoprostane (8-Iso-Prostaglandin F_2α) in Immature Pig Periventricular Brain Microvessels

Abstract

15-F(2t)-IsoP causes periventricular brain region vasoconstriction in the fetus that is greater than that in the newborn, which in turn is greater than that in the juvenile due to greater TXA(2) formation generated through distinct stimulatory pathways, including from endothelial and astroglial cells. The resulting hemodynamic compromise may contribute to the increased vulnerability of the periventricular brain areas to oxidant stress-induced injury in immature subjects.