Early implant healing: promotion of platelet activation and cytokine release by topographical, chemical and biomimetical titanium surface modifications <i>in vitro</i>

Abstract

Modifications of surface roughness modifications appear to influence early platelet activation and cytokine release after 15 min whereas surface chemistry modifications with increased hydrophilic properties and surface modifications via RGD peptide on plainer surfaces lead to a further, more specific promotion of platelet activation and degranulation after 30 min. The observed effect could be valuable for critical clinical situations like compromised bone sites.