An inherited qualitative abnormality in plasma fibrinogen: fibrinogen Cleveland.

Abstract

Abstract A family has been observed in which the plasma of affected individuals contains an abnormal fibrinogen, tentatively designated as fibrinogen Cleveland. The trait, inherited in an autosomal manner, was recognized by a delay in clotting upon the addition of thrombin to plasma. The defect in fibrinogen appeared to reside in an inability of dissolved fibrin monomers or polymers to aggregate into a visible clot. Immunoelectrophoretic behavior and certain other characteristics seem to distinguish this fibrinogen from other inherited abnormalities of this protein.