Involvement of heparan sulfate 3‐<i>O</i>‐sulfotransferase isoform‐1 in the insulin secretion pathway

Abstract

Our data suggest that the 3-O-sulfate group of HS that is modified by Hs3st1 plays a significant role(s) in the insulin secretory pathway, selectively through an interaction with factor(s) upstream of membrane depolarization in β-cells. (J Diabetes Invest, doi: 10.1111/j.2040-1124.2012.00205.x, 2012).