Susceptibility for and clinical manifestations of rheumatoid arthritis are associated with polymorphisms of the TNF-alpha, IL-1beta, and IL-1Ra genes. - Concepedia

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Susceptibility for and clinical manifestations of rheumatoid arthritis are associated with polymorphisms of the TNF-alpha, IL-1beta, and IL-1Ra genes.

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2002

Year

Jasmina Trifunovic Cvetkovic, Solveig Wållberg‐Jonsson, Birgitta Stegmayr, Solbritt Rantapää‐Dahlqvist, Ann Kari Lefvert

Abstract

The Al allele of TNF-alpha associates with RA. Genotypes A1A2 of TNF-alpha and A2A2 of IL-1beta are associated with more severe disease. The allelic combination A1IL-1beta/A2 IL-1Ra is less often present in RA patients who developed cardiovascular complications.