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Macrophage colony-stimulating-factor (M-CSF or CSF-1) and its receptor: structure-function relationships.

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1997

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Abstract

INTRODUCTION The macrophage colony-stimulating-factor (M-CSF or CSF-1) was initially described as an hematopoietic growth factor required for the survival, proliferation, differentiation and a variety of other functions of cells of the monocyte/macrophage lineage [1-4]. It also synergizes with others cytokines to induce the proliferation of earlier hematopoietic progenitors [5, 6]. More recently, a role of M-CSF in immunological [...]