Copper‐Mediated Synthesis of Aryldifluoromethylphosphonates: A Sandmeyer Approach

Abstract

Abstract Difluoromethylated arenes are scaffolds of great interest. We report herein a mild and general method for the introduction of the CF 2 PO(OEt) 2 moiety into arenes. The CuCF 2 PO(OEt) 2 species, which is generated in situ from the corresponding silylated derivatives, in combination with aryl diazonium salts furnished the highly valuable aryl difluoromethylphosphonates in moderate to good yields. This represents the first general method to introduce difluoromethylphosphonates under mild conditions.