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The effect of methotrexate on chemical carcinogenesis of hamster buccal pouch.
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1966
Year
Tumor BiologyComparative ToxicologyMalignant DiseaseMedicinePharmacologyVeterinary ScienceCancer Cell BiologyPathologyChemical CarcinogenesisHamster Buccal PouchToxicologyToxicological AspectExperimental ToxicologyOncologyRadiation OncologyBuccal PouchSummary Forty-eight MaleCancer Research
Summary Forty-eight male and female Syrian hamsters, 6 months of age, were studied for the effects of systemically injected methotrexate upon the process of chemical carcinogenesis of buccal pouch. Twelve animals (Group I) had the right buccal pouch painted 3 times weekly with a 0.5% solution of 9, 10-dimethyl-1,2-benzanthracene (DMBA) in heavy mineral oil. Twelve animals (Group 2) were painted with DMBA and also injected s.c. 3 times weekly with 0.0625 mg sodium methotrexate. Remaining animals served as control groups. In those animals given injections of methotrexate, chemically induced carcinomas of the buccal pouch appeared more rapidly than in DMBA controls. The tumors were also more anaplastic and of greater size.