MR of human postmortem brain tissue: correlative study between T2 and assays of iron and ferritin in Parkinson and Huntington disease.

Abstract

Our results indicate that tissue iron and ferritin concentrations are elevated in the brains of subjects with both Parkinson and Huntington disease but the elevated concentrations do not correlate with T2 shortening. Although iron and ferritin can shorten T2, we conclude that other factors must play a significant role in determining the T2 relaxation time and that iron or ferritin are not dominant in this regard.