Deletion of the distal COOH‐terminus of the A_2Badenosine receptor switches internalization to an arrestin‐ and clathrin‐independent pathway and inhibits recycling

Abstract

Deletion of the COOH-terminus of the A(2B) adenosine receptor beyond Leu(330) switches internalization from an arrestin- and clathrin-dependent pathway to one that is dynamin dependent but arrestin and clathrin independent. The presence of a Type II PDZ motif appears to be essential for arrestin- and clathrin-dependent internalization, as well as recycling of the A(2B) adenosine receptor following prolonged agonist addition.