Phase I and pharmacologic study of oral topotecan administered twice daily for 21 days to adult patients with solid tumors. - Concepedia

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Phase I and pharmacologic study of oral topotecan administered twice daily for 21 days to adult patients with solid tumors.

75

Citations

10

References

1997

Year

G.J. Creemers, C J Gerrits, John R. Eckardt, Jan H.M. Schellens, Howard A. Burris, André Planting, G I Rodriguez, Walter J. Loos, I Hudson, Colin Broom,

Journal of Clinical Oncology

Abstract

The DLT in this phase I study for chronic oral topotecan for 21 days was diarrhea. The recommended dose for phase II studies is 0.5 mg/m2 twice daily.

References

	Year	Citations

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