Inhibition of CYP2D6‐mediated tramadol O‐demethylation in methadone but not buprenorphine maintenance patients

Abstract

Methadone inhibited the CYP2D6-mediated metabolism of tramadol to M1. Hence, as the degree of opioid analgesia is largely dependent on M1 formation, methadone maintenance patients may not receive adequate analgesia from oral tramadol.