The orally active urotensin receptor antagonist, <scp>KR</scp>36676, attenuates cellular and cardiac hypertrophy

Abstract

A highly potent UT receptor antagonist exerted anti-hypertrophic effects not only in infarcted rat hearts but also in pressure-overloaded mouse hearts. KR36676 could be a valuable pharmacological tool in elucidating the complicated physiological role of U-II and UT receptors in cardiac hypertrophy.