Double-Homozygosity for Factor V Leiden and the Prothrombin Gene G20210A Variant in a Young Patient With Idiopathic Venous Thrombosis

Abstract

To the Editor: There is growing evidence that environmental and genetic risk factors often interact to induce clinically manifest venous thromboembolism (VTE). The role of gene-gene interactions, although much rarer, is supported by cosegregation of genetic defects observed in patients with