Heterozygous Germline <i>ATM</i> Mutations Do Not Contribute to Radiation-Associated Malignancies After Hodgkin's Disease

Abstract

Analysis of the number of tumors per individual and the family history of cancer in our cohort suggests that genetic factors may contribute to development of secondary neoplasms in a subset of Hodgkin's disease survivors. Mutational analysis, however, does not support a significant role for heterozygous truncating ATM mutations. Future studies evaluating other genes involved in DNA damage response pathways are warranted.