Dexrazoxane protects the heart from acute doxorubicin‐induced QT prolongation: a key role for<i>I</i>_Ks

Abstract

Doxorubicin acutely prolonged the QT interval in guinea-pig heart by selective I(Ks) blockade. This effect was prevented by dexrazoxane. This result is important because it illustrates the danger of neglecting I(Ks) in favour of hERG screening alone, for early preclinical testing for possible induction of torsade de pointes.