Concepedia

Gain‐of‐Function <i>KCNH2</i> Mutations in Patients with Brugada Syndrome

Qi Wang, Seiko Ohno, Wei-Guang Ding, Megumi Fukuyama, Akashi Miyamoto, Hideki Itoh, Takeru Makiyama, Jie Wu, Jiayu Bai, Kanae Hasegawa,

Journal of Cardiovascular Electrophysiology · 2014 · 43 citations · 17 references

DOI

Abstract

All KCNH2 mutations that we identified in probands with BrS exerted gain-of-function effects on I(Kr) channels, which may partially explain the ECG findings in our patients.

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