Pioglitazone, a ligand for peroxisome proliferator-activated receptor-gamma acts as an inhibitor of colon cancer liver metastasis. - Concepedia

Concepedia

Publication | Closed Access

Pioglitazone, a ligand for peroxisome proliferator-activated receptor-gamma acts as an inhibitor of colon cancer liver metastasis.

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Citations

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References

2009

Year

Shota Takano, Tetsuro Kubota, Hideki Nishibori, Hirotoshi Hasegawa, Yoshiyuki Ishii, Nobuhiro Nitori, Hiroki Ochiai, Koji Okabayashi, Yuko Kitagawa, Masahiko Watanabe,

Abstract

PGZ down-regulates COX-2 and cyclin D1 and inhibits colon cancer proliferation and liver metastasis, making PPARgamma a candidate target for the treatment/prevention of colon cancer metastasis.