Quantifying non‐covalent binding affinity using mass spectrometry: A systematic study on complexes of cyclodextrins with alkali metal cations

Abstract

The binding constants of non-covalent cyclodextrin-alkali cation complexes have been systematically studied by an improved mass spectrometric titration and competitive ESI-MS. Also, the structural features of the complexes were discussed. Our results are valuable for better understanding of mechanisms driving inclusion chemistry under well-defined conditions.