The Effects of Cyclooxygenase2–ProstaglandinE2 Pathway on<i>Helicobacter pylori</i>‐Induced Urokinase‐Type Plasminogen Activator System in the Gastric Cancer Cells

Abstract

Our results indicated that COX2-PGE2 pathway may be involved in H. pylori-associated uPA and uPAR induction, and that COX-2 inhibitor or EP2 receptor antagonist may inhibit angiogenesis and tumor invasion via suppression of the uPA system.