<i>GBA</i> Variants are associated with a distinct pattern of cognitive deficits in <scp>P</scp>arkinson's disease

Abstract

Both GBA mutations and E326K are associated with a distinct cognitive profile characterized by greater impairment in working memory/executive function and visuospatial abilities in PD patients. The discovery that E326K negatively impacts cognitive performance approximately doubles the proportion of PD patients we now recognize are at risk for more severe GBA-related cognitive deficits.