Attenuated <i>Bordetella pertussis</i> Vaccine Protects against Respiratory Syncytial Virus Disease via an IL-17–Dependent Mechanism

Abstract

Rather than enhancing RSV disease, BPZE1 protected against viral infection, modified viral responses, and enhanced natural mucosal resistance. Prevention of RSV infection by BPZE1 seems in part to be caused by induction of IL-17. Clinical trial registered with www.clinicaltrials.gov (NCT 01188512).