The NF-κB p65 and p50 homodimer cooperate with IRF8 to activate iNOS transcription

Abstract

IFNγ-induced IRF8 acts in concert with NF-κB to regulate iNOS expression in both colon carcinoma and myeloid cells. In myeloid cells, the NF-κB complexes that bind to the nos2 promoter are p65/p65 and p50/p50 homodimers.