Synergistic Elevations in Nucleus Accumbens Extracellular Dopamine Concentrations during Self-Administration of Cocaine/Heroin Combinations (Speedball) in Rats

A psychomotor stimulant theory of addiction.

Roy A. Wise, Michael A. Bozarth · Psychological Review · 1987 · 2.7K citations

Medicine, Neuroscience, Pharmacology +17

Opioids excite dopamine neurons by hyperpolarization of local interneurons

SW Johnson, RA North · Journal of Neuroscience · 1992 · 1.6K citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens

David C. S. Roberts, George F. Koob, P. Klonoff et al. · Pharmacology Biochemistry and Behavior · 1980 · 726 citations

Medicine, Neurobiology, Neuroscience +16

Relationship between subjective effects of cocaine and dopamine transporter occupancy

Nora D. Volkow, G J Wang, Marian W. Fischman et al. · Nature · 1997 · 654 citations

Medicine, Neurobiology, Neuroscience +13

Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats

Hugh O. Pettit, Aaron Ettenberg, Floyd E. Bloom et al. · Psychopharmacology · 1984 · 653 citations

Medicine, Neurobiology, Neuroscience +12