EFFECT OF HEMIGRAPHIS COLORATA (BLUME) H. G. HALLIER LEAF ON WOUND HEALING AND INFLAMMATION IN MICE

Abstract

Objective: To study the wound healing and anti-inflammatory properties of Hemigraphis colorata (leaf). Methods: The wound healing property of H. colorata leaf paste (topical application) or suspension (p.o., 1g/kg) was studied using excision wound which was inflicted by cutting away 500 mm 2 of the skin on the anterio-dorsal side of mouse. The anti- inflammatory activity of the leaf was evaluated using carrageenaninduced paw oedema model in mice. Results: H. colorata leaf paste when applied on the wound promoted wound healing in mice but oral administration was ineffective. The wound contraction and epithelialisation was faster in the leaf paste applied on mice. The leaf suspension or paste was devoid of anti-inflammatory activity. Conclusion: H. colorata leaf paste promotes excision wound healing in mice.