Synthesis of α-enamino esters via Cu(<scp>ii</scp>)-promoted dehydrogenation of α-amino acid esters: application to the synthesis of polysubstituted pyrroles

Abstract

α-Enamino esters are synthesized from α-amino acid esters using Cu(<sc>ii</sc>)-promoted dehydrogenation. Application of the α-enamino esters to the synthesis of polysubstituted pyrroles is achieved through oxidative coupling with alkynes under Cu(<sc>ii</sc>)-promoted conditions.