Infection and Immunity · 1983 · 123 citations · 9 references
Life SciencesMicrobiologyPharmacologyAntimicrobial ResistanceBacteriologyMedical MicrobiologyAntibacterial AgentsAntibacterial PharmacologyAntibiotic ResistanceAntimicrobial PeptidesBacterial InfectionsPulmonary InfectionsAntibacterial PeptidesAntimicrobial Peptide ActivityBactericidal AgentsCationic Antimicrobial PeptidesEscherichia ColiHost Antimicrobial PeptidesPeptide Structure-activity RelationshipsStreptococcus Species
Microbicidal cationic proteins 1 and 2, peptides derived from rabbit lung macrophages, were tested for bactericidal activity against various bacterial species. Both were highly active against diverse gram-positive and gram-negative organisms under conditions of near-neutral pH (between 7 and 8) and relatively low ionic strength. Susceptible species included Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Listeria monocytogenes, Pseudomonas aeruginosa, Klebsiella pneumoniae, Haemophilus influenzae, Escherichia coli, and Serratia marcescens. Streptococcus agalactiae, type 1A, was less susceptible than the aforementioned organisms or S. agalactiae, type 3. Bordetella bronchiseptica, a common commensal and pathogen of the rabbit respiratory tract, was completely resistant to both peptides.
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The respiratory burst of phagocytic cells is associated with a rise in vacuolar pH
Anthony W. Segal, Michael J. Geisow, Rodolfo García et al. · Nature · 1981 · 427 citations