Concepedia

Publication | Closed Access

Simvastatin inhibits cytokine production and nuclear factor-kB activation in interleukin 1beta-stimulated synoviocytes from rheumatoid arthritis patients.

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Citations

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References

2008

Year

Pietro Enea Lazzerini, Sauro Lorenzini, Enrico Selvi, Pier Leopoldo Capecchi, Daniela Chindamo, Stefania Bisogno, Raffaella Ghittoni, Mariarita Natale, Francesca Caporali, S Giuntini,
PubMed

Abstract

Simvastatin significantly inhibits the production of IL-6 and IL-8 also in IL-1-stimulated FLS, even though to a lesser extent than in unstimulated cells, via a HMG-CoA-reductase block with an interference in prenylation process and NF-kB activation. Our results further support the rationale for the use of statins in the treatment of rheumatoid synovitis.