Tenofovir‐based rescue therapy for chronic hepatitis <scp>B</scp> patients who had failed treatment with lamivudine, adefovir, and entecavir

Abstract

TDF/ETV combination therapy was not associated with higher rate of VR compared with TDF/LAM combination therapy in MDR CHB patients. These results raise the suspicion about the superiority of the combination therapy over TDF monotherapy. The lower HBV-DNA levels at the start of TDF-based rescue therapy were associated with higher VR.