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Characterization of the inflammatory and immune effector cells in the lung parenchyma of patients with interstitial lung disease.
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1981
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Acute Lung InjuryAsthmaInflammatory Lung DiseaseAdvanced Lung DiseaseLung InflammationImmunologyImmune Effector CellsPathologyPulmonary Alveolar ProteinosisInflammationNormal LungRespiratory InfectionPulmonary PharmacologyAutoimmune DiseaseAllergyPulmonary PathologyAlveolar BiologyLung ParenchymaAutoimmunityPulmonary FibrosisPulmonary DiseaseInterstitial Lung DisordersBronchial NeoplasmInfectious Respiratory DiseaseMedicineMatrikines
The pathogenesis of interstitial lung disorders is closely linked to the number, type, and activation state of inflammatory and immune effector cells (alveolitis) within alveolar structures. The study developed a method to isolate and directly characterize the cells comprising alveolitis in idiopathic pulmonary fibrosis and sarcoidosis patients from open lung biopsies. Using this method, the authors compared the phenotypic composition of isolated cells to normal lung effector cells, revealing distinct cellular profiles between disease and healthy tissue.
The pathogenesis of the interstitial lung disorders is intimately related to the number, type, and state of activation of inflammatory and immune effector cells (the alveolitis) within the alveolar structures. To directly characterize the type and status of the cells comprising the alveolitis of various interstitial lung disorders, a method was developed to isolate inflammatory and immune effector cells from open lung biopsies of patients with idiopathic pulmonary fibrosis (n = 9) and sarcoidosis (n = 6). The cells isolated from these biopsies were compared with effector cells obtained from normal lung (n = 3). The effector cell populations in normal lung contained alveolar macrophages (84 ± 17%), lymphocytes (16 ± 4%), and rare polymorphonuclear leukocytes (<1%); of the lymphocytes present, 73 ± 4% were T-lymphocytes, 7 ± 2% were “activated” T-lymphocytes, and 9 ± 2% were B-lymphocytes. In contrast, a characteristic feature of the alveolitis of idiopathic pulmonary fibrosis was the presence of increased ...