One-pot synthesis of functionalized isoxazole–thiolane hybrids via Knoevenagel condensation and domino sulfa-1,6-Michael/intramolecular vinylogous Henry reactions

Abstract

One-pot synthesis of isoxazole–thiolane hybrids are reported <italic>via</italic> the Knoevenagel condensation, domino sulfa-1,6-Michael/intramolecular vinylogous Henry reactions using piperidine (30 mol%) with &gt;95% yields in 2–2.5 h overall reaction time.