Mice overexpressing wild‐type human alpha‐synuclein display alterations in colonic myenteric ganglia and defecation

Abstract

The occurrence of over-production of pre-synaptic α-synuclein in colonic myenteric ganglia several months before the loss of striatal dopamine may provide an anatomical basis for interference with cholinergic neuronal activation, causing an early impairment in defecation to stimuli.