Modulation of <scp>K_v7</scp> potassium channels by a novel opener pyrazolo[1,5‐a]pyrimidin‐7(<scp>4H</scp>)‐one compound <scp>QO</scp>‐58

Abstract

The results indicate that QO-58 is a potent modulator of K(v)7 channels with a mechanism of action different from those of known K(v)7 openers. Hence, QO-58 shows potential as a treatment for diseases associated with neuronal hyperexcitability.