Synthesis and antitumor activity of 5-(5-halogenated-2-oxo-1H-pyrrolo[2,3-b]pyridin-(3Z)-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxamides

Discovery of 5-[5-Fluoro-2-oxo-1,2- dihydroindol-(3<i>Z</i>)-ylidenemethyl]-2,4- dimethyl-1<i>H</i>-pyrrole-3-carboxylic Acid (2-Diethylaminoethyl)amide, a Novel Tyrosine Kinase Inhibitor Targeting Vascular Endothelial and Platelet-Derived Growth Factor Receptor Tyrosine Kinase

Li Sun, Chris Liang, Sheri Shirazian et al. · Journal of Medicinal Chemistry · 2003 · 520 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Meriolins (3-(Pyrimidin-4-yl)-7-azaindoles): Synthesis, Kinase Inhibitory Activity, Cellular Effects, and Structure of a CDK2/Cyclin A/Meriolin Complex

Aude Echalier, Karima Bettayeb, Yoan Ferandin et al. · Journal of Medicinal Chemistry · 2008 · 163 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Novel Fluoroquinolone Antibacterial Agents Containing Oxime-Substituted (Aminomethyl)pyrrolidines:  Synthesis and Antibacterial Activity of 7-(4-(Aminomethyl)-3-(methoxyimino)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro- 4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylic Acid (LB20304)^,1

Chang Yong Hong, Young Kwan Kim, Jay Hyok Chang et al. · Journal of Medicinal Chemistry · 1997 · 127 citations

Natural Sciences, Chemistry, Medicinal Chemistry +14

Synthesis and Structure−Activity Relationships of Novel 7-Substituted 1,4-Dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic Acids as Antitumor Agents. Part 2

Yasunori Tsuzuki, Kyoji Tomita, K. SHIBAMORI et al. · Journal of Medicinal Chemistry · 2004 · 87 citations

Pharmacy, Medicinal Chemistry, Pharmacology +14

Novel Potent Orally Active Multitargeted Receptor Tyrosine Kinase Inhibitors: Synthesis, Structure−Activity Relationships, and Antitumor Activities of 2-Indolinone Derivatives

Peng Tang, Yi Dong Su, Jun Feng et al. · Journal of Medicinal Chemistry · 2010 · 50 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15