Upregulation of regulator of G-protein signaling 2 in the sclera of a form deprivation myopic animal model.

Abstract

We identified a significant RGS2 upregulation and collagen type I downregulation in the sclera of FDM eyes, which could be partially attenuated by atropine treatment. Our data suggest that targeting dysregulated RGS2 may provide a novel strategy for development of therapeutic agents to suppress myopia progression.