Serial studies of gastric secretion in patients after highly selective (parietal cell) vagotomy without a drainage procedure for duodenal ulcer. I. Effect of highly selective vagotomy on basal and pentagastrin-stimulated maximal acid output.

Abstract

Serial tests of basal acid output (BAO) and maximal acid output (MAO) were performed in patients with chronic duodenal ulceration, before operation, and 1 week, 2 to 3 months, 6 to 12 months, and 12 to 24 months after highly selective vagotomy (HSV) without a drainage procedure. Dose-response studies showed that the dose of pentagastrin used was sufficient to elicit MAO in patients after HSV. The results obtained in Leeds and Copenhagen were very similar. BAO was reduced by a mean of 92% at 1 week, 86% at 2 to 3 months, 87% at 6 to 12 months, and 80% beyond 1 year. BAO increased significantly between 3 months and 12 to 24 months after HSV (P