Genetic deletion of the <scp>H</scp>istone <scp>D</scp>eacetylase 6 exacerbates selected behavioral deficits in the R6/1 mouse model for Huntington's disease

Abstract

These results weaken the validity of HDAC6 reduction as a possible therapeutic strategy for HD. The data are discussed in terms of additional cellular consequences and anatomical specificity of HDAC6 that could explain these unexpected effects.