Disulfide-Containing High Mobility Group Box-1 Promotes <i>N</i> -Methyl- <scp>d</scp> -Aspartate Receptor Function and Excitotoxicity by Activating Toll-Like Receptor 4-Dependent Signaling in Hippocampal Neurons

Abstract

We describe a novel molecular neuronal pathway activated by HMGB1 that could be targeted in vivo to prevent neurodegeneration and seizures mediated by excessive NMDARs stimulation.