Degradation of Cardiac Troponin I in Serum Complicates Comparisons of Cardiac Troponin I Assays

Abstract

The availability of serum cTnI epitopes is markedly affected by the extent of ligand degradation. The N-terminal half of the cTnI molecule was found to be the most stable region in human serum. Differential degradation of cTnI is a key factor in assay-to-assay variation.