Interactive Effects of<i>Cyp3A4, Cyp3A5, Mdr1</i>and<i>Nr1I2</i>Polymorphisms on Tracrolimus Trough Concentrations in Early Postrenal Transplant Recipients

Abstract

CYP3A5*3 was the predominant determinant affecting tacrolimus concentration. Genotyping of CYP3A4/MDR1/NR1I2 polymorphisms may be helpful for better guiding tacrolimus dosing in CYP3A5 nonexpressers.