Synthèse d'analogues structuraux de l'élédoïsine (3ème partie)

Abstract

Abstract The syntheses of a large number of Eledoisin analogues, some of which possess a more potent depressor effect than the original peptide, are described. Whereas the C‐terminal moiety of the Eledoisin molecule seems to be responsible for its biological action, its N‐terminal moiety can be deeply modified or even left out without considerable decrease of activity. There is apparently no relation between the isoelectric points of these analogous peptides and their biological properties.