Arylsulfonylmethyl isocyanides: a novel paradigm in organic synthesis

Abstract

<italic>p</italic>-Tosylmethyl isocyanide (TosMIC), an α-acidic isocyanide has emerged as a privileged reagent to access biologically relevant fused heterocycles and some natural products like (−)-ushikulide A, variolin B, porphobilinogen and mansouramycin B.