Observations on inhibition of nucleic acid synthesis resulting from administration of nitrogen mustard, urethan,. colchicine, 2,6-diaminopurine, 8-azaguanine, potassium arsenite, and cortisone.

Abstract

Using the technic of measuring the incorporation of formate carbon into nucleic acid purines of control and treated mice, data have been obtained which indicate that 2,6-diaminopurine, 8-azaguanine, cortisone, potassium arsenite, urethan, and nitrogen mustard inhibit nucleic acid synthesis in vivo . Benzene and colchicine have been relatively ineffective as inhibitors of nucleic acid synthesis under the conditions of these experiments.