Concepedia

Efficient Synthesis of 3-Pyrrolin-2-one Derivatives in Aqueous Media

Adeleh Moshtaghi Zonouz, Issa Eskandari, Behrouz Notash

Synthetic Communications · 2015 · 17 citations · 15 references

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Abstract

An efficient one-pot, three-component synthesis of 3-pyrrolin-2-ones in aqueous media at room temperature is reported. This reaction provides a green and catalyst-free method for generation of 3-pyrrolin-2-one derivatives in good yields.

References

15

Strategies for Innovation in Multicomponent Reaction Design

Bruce Ganem · Accounts of Chemical Research · 2009 · 1.2K citations · Full text

, , +14

Perspective on Solvent Use in the Pharmaceutical Industry

David J. C. Constable, Conchita Jimenez-Gonzalez, Richard K. Henderson · Organic Process Research & Development · 2006 · 728 citations

, , +16

A Novel [3+2] Cycloaddition Approach to Nitrogen Heterocycles via Phosphine-Catalyzed Reactions of 2,3-Butadienoates or 2-Butynoates and Dimethyl Acetylenedicarboxylate with Imines:  A Convenient Synthesis of Pentabromopseudilin

Zhenrong Xu, Xiyan Lu · The Journal of Organic Chemistry · 1998 · 331 citations

, , +11

Molecular diversity by design

Stuart L. Schreiber · Nature · 2009 · 293 citations · Full text

, , +2

Expanding GSK?s Solvent Selection Guide?application of life cycle assessment to enhance solvent selections

Concepci�n Jim�nez-Gonz�lez, Alan D. Curzons, David J. C. Constable et al. · Clean Technologies and Environmental Policy · 2004 · 267 citations

, , +16